Their was many consequences of Native Americans coming in contact with European Settlers.One of which is deadly diseases that Natives had not been exposed to before. Another impact was European weapons.European weapons were fare more powerful and advanced, so Natives stood no fighting chance with the Europeans. Another key and very important impact was Spanish Missions. The Spanish set up small missions along to islands of Georgia. On these islands Natives were coveted to Christianity. I believe these missions were didn't work because it was ether you get shot or you convert.Finally, Europeans stole land from the Natives causing the Trail of Tears.